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"IGF1R", "IKKA", "IKKB", "IKKE", "INSR", "INSRR", "IRAK1", "IRAK3", "IRAK4", "ITK", "JAK1(JH1domain-catalytic)", "JAK1(JH2domain-pseudokinase)", "JAK2(JH1domain-catalytic)", "JAK3(JH1domain-catalytic)", "JNK1", "JNK3", "KC1G1", "KC1G2", "KCC2D", "KCC4", "KGP1", "KGP2", "KIT", "KIT(A829P)", "KIT(D816H)", "KIT(D816V)", "KIT(L576P)", "KIT(V559D)", "KIT(V559D,T670I)", "KIT(V559D,V654A)", "KKCC1", "KPCD", "KPCD1", "KPCD2", "KPCD3", "KPCE", "KPCI", "KPCL", "KPCT", "LATS1", "LATS2", "LCK", "LIMK1", "LIMK2", "LKB1", "LOK", "LRRK2", "LRRK2(G2019S)", "LTK", "LYN", "M3K12", "M3K13", "M3K2", "M3K5", "M3K6", "M4K1", "M4K3", "MAK", "MAP3K1", "MAP3K15", "MAP3K3", "MAP3K4", "MAP4K2", "MAP4K4", "MAP4K5", "MAPKAPK2", "MAPKAPK5", "MARK1", "MARK2", "MARK3", "MARK4", "MAST1", "MELK", "MERTK", "MET", "MET(M1250T)", "MET(Y1235D)", "MINK", "MK01", "MK03", "MK09", "MK11", "MK12", "MK13", "MK14", "MKNK1", "MKNK2", "MLCK", "MLK1", "MLK2", "MLK3", "MLTK", "MP2K1", "MP2K2", "MP2K3", "MP2K4", "MP2K5", "MP2K6", "MP2K7", "MRCKA", "MRCKB", "MST1", "MST1R", "MST2", "MST3", "MST4", "MTOR", "MUSK", "MYLK", "MYLK2", "MYLK4", "MYO3A", "MYO3B", "NDR1", "NDR2", "NEK1", "NEK11", "NEK2", "NEK3", "NEK4", "NEK5", "NEK6", "NEK7", "NEK9", "NIM1", "NLK", "NUAK1", "OSR1", "PAK1", "PAK2", "PAK3", "PAK4", "PAK6", "PAK7", "PCTK2", "PCTK3", "PDPK1", "PFCDPK1(P.falciparum)", "PFPK5(P.falciparum)", "PGFRA", "PGFRB", "PHKG1", "PHKG2", "PI42C", "PIK3C2B", "PIK3C2G", "PIK3CA", "PIK3CA(C420R)", "PIK3CA(E542K)", "PIK3CA(E545A)", "PIK3CA(E545K)", "PIK3CA(H1047L)", "PIK3CA(H1047Y)", "PIK3CA(I800L)", "PIK3CA(M1043I)", "PIK3CA(Q546K)", "PIK3CB", "PIK3CD", "PIK3CG", "PIK4CB", "PIM1", "PIM2", "PIM3", "PIP5K1A", "PIP5K1C", "PIP5K2B", "PKAC-alpha", "PKAC-beta", "PKMYT1", "PKN1", "PKN2", "PKNB(M.tuberculosis)", "PLK1", "PLK2", "PLK3", "PLK4", "PRKR", "PRKX", "PRP4", "PTK6", "RAF1", "RET", "RET(M918T)", "RET(V804L)", "RET(V804M)", "RIOK1", "RIOK2", "RIOK3", "RIPK1", "RIPK2", "RIPK4", "RIPK5", "ROCK1", "ROCK2", "ROS1", "RPS6KA4(Kin.Dom.1-N-terminal)", "RPS6KA4(Kin.Dom.2-C-terminal)", "RPS6KA5(Kin.Dom.1-N-terminal)", "RPS6KA5(Kin.Dom.2-C-terminal)", "RSK1(Kin.Dom.1-N-terminal)", "RSK1(Kin.Dom.2-C-terminal)", "RSK2(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.2-C-terminal)", "RSK4(Kin.Dom.1-N-terminal)", "RSK4(Kin.Dom.2-C-terminal)", "S6K1", "SBK1", "SgK110", "SGK3", "SIK1", "SIK2", "SIK3", "SLK", "SNARK", "SNRK", "SRC", "SRMS", "SRPK1", "SRPK2", "SRPK3", "STK16", "STK33", "STK35", "STK36", "STK39", "SYK", "TAK1", "TAOK1", "TAOK2", "TAOK3", "TBK1", "TEC", "TESK1", "TGFBR1", "TGFBR2", "TIE1", "TIE2", "TLK1", "TLK2", "TNIK", "TNK1", "TNK2", "TNNI3K", "TRKA", "TRKB", "TRKC", "TRPM6", "TSSK1", "TTK", "TXK", "TYK2(JH1domain-catalytic)", "TYK2(JH2domain-pseudokinase)", "TYRO3", "ULK1", "ULK2", "ULK3", "VGFR1", "VGFR2", "VRK2", "WEE1", "WEE2", "YANK1", "YANK2", "YANK3", "YES", "YSK1", "YSK4", "ZAP70" ], "_version_": 1815487279418834944 }, { "centerdatasetid": "http://lincs.hms.harvard.edu/db/datasets/20087/", "funding": "1U54HG006097-01", "projectname": "LINCS phase 1", "assayoverview": "The KiNativ assay platform is based on the use of biotinylated acyl phosphates of ATP or ADP that act as probes by reacting with protein kinases on conserved lysine residues in the ATP binding pocket to covalently attach a biotin moiety. Using these probes, cell lysates treated with a kinase inhibitor can be labeled with BHAcATP or BHAcADP, with kinases inhibited by the compound of interest exhibiting reduced or no labeling. This is followed by digestion with trypsin, isolation of biotinylated peptides, and analysis by mass spectrometry to determine the extent of labeling of peptides from each kinase.", "centerurl": "http://lincs.hms.harvard.edu", "description": "-", "principalinvestigator": "Nathanael Gray", "centerfullname": "HMS LINCS (Harvard Medical School)", "centername": "HMS_LINCS", "ldplink": "http://lincsportal.ccs.miami.edu/datasets/#/view/LDS-1073", "path": "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS", "protocol": "LDG-1070_Protocol.pdf", "datemodified": "2015-10-06", "centerletter": "H", "screeninglabinvestigator": "Qingsong Liu", "datasetname": "Sorafenib KiNativ -- dose response experiment", "datasetid": "LDS-1073", "id": "7785", "datereleased": "2011-07-15", "assayname": [ "KiNativ kinase-small molecule binding assay" ], "assayformat": "Biochemical", "assaydesignmethod": [ "KiNativ" ], "physicaldetection": "Mass spectrometry", "biologicalprocess": [ "Small molecule metabolic process" ], "technologies": "KiNativ", "biologicalbucket": "Binding", "endpointcategorization": "Protein binding profile", "endpoints": [ "IC50" ], "levelspath": [ "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS" ], "datasetlevels": [ "LDS-1073" ], "latestversions": [ "2.0" ], "datalevels": [ "3" ], "size": [ "11583" ], "versions": [ "LDS-1073:1.0;2.0" ], "datasetgroup": "LDG-1070", "concentrations": [ "0.01 uM, 0.1 uM, 1 uM, 10 uM" ], "timepoints": [ "" ], "expentimentalcomments": [ "" ], "toollink": [ "http://life.ccs.miami.edu/life/search?load\u003dAssayTypeName\u0026search\u003dconcept%3A%26quot%3BKiNativ+assay%26quot%3B\u0026q\u003dconcept%3A%26quot%3BKiNativ+assay%26quot%3B", "http://amp.pharm.mssm.edu/Harmonizome/dataset/LINCS+Kinativ+Kinase+Inhibitor+Bioactivity+Profiles" ], "tool": [ "Life", "Harmonizome" ], "statsfields": [ "protein", "smallmolecule", "cellline" ], "counts": [ "protein:217", "smallmolecule:1", "cellline:1" ], "statsvalues": [ "217", "1", "1" ], "smlincsidentifier": [ "LSM-1008" ], "cellline": [ "A-375" ], "protein": [ "ABL,ARG", "ACK", "AGK", "AKT1", "AKT2,AKT3", "AMPKa1,AMPKa2", "ARAF", "ATM", "ATR", "AurA", "AurA,AurB,AurC", "AXL", "BRAF", "CaMK1a", "CaMK2g", "CaMKK2", "CASK", "CDC2", "CDK10", "CDK11,CDK8", "CDK14", "CDK16", "CDK2", "CDK4", "CDK5", "CDK6", "CDK7", "CDK9", "CHK1", "CHK2", "CK1d,CK1e", "CSK", "DMPK", "DNAPK", "eEF2K", "EGFR", "EPHA2", "Erk5", "FAK", "FER", "FYN,SRC,YES", "FYV1", "GCK", "GCN2_domain2", "GSK3A", "GSK3B", "IKKA", "IKKB", "IKKE,TBK1", "ILK", "IRAK1", "IRAK4", "IRE1", "ITPK1", "JAK1", "JAK1_domain2", "JNK1,JNK2,JNK3", "KC1A", "KCC2D", "KHS1", "KPCT", "KS6B1", "KS6B2", "LATS1", "LKB1", "LOK", "LRRK2", "M3K2", "M3K2,MAP3K3", "MAP2K1", "MAP2K1,MAP2K2", "MAP2K3", "MAP2K4", "MAP2K5", "MAP2K6", "MAP3K1", "MAP3K3", "MAP3K4", "MAP3K5,MAP3K6,MAP3K7", "MAP3K7,TAK1", "MARK1", "MARK2", "MARK2,MARK3", "MARK3", "MAST1,MAST2", "MAST2,MAST4", "MAST3", "MASTL", "MK03", "MLK3", "MLKL", "MLTK", "MP2K7", "MPSK1", "MSK1_domain1", "MSK1,MSK2_domain1", "MST1", "MST1,MST2", "MST2", "MST3", "MST3,MST4,YSK1", "MST4,YSK1", "NDR1", "NDR1,NDR2", "NDR2", "NEK1", "NEK6,NEK7", "NEK7", "NEK8", "NEK9", "OSR1", "p38d,p38g", "p70S6K,p70S6Kb", "PCTAIRE2", "PCTAIRE2,PCTAIRE3", "PHKg2", "PI42C", "PI4KA,PI4KAP2", "PI4KB", "PIK3C3", "PIK3CA", "PIK3CB", "PIK3CD", "PIP4K2A", "PITSLRE", "PKCa,PKCb", "PKD1", "PKD1,PKD2", "PKD2", "PKD3", "PKN2", "PKR", "PLK1", "PRKACB", "PRPK", "RAF1", "ROCK1,ROCK2", "RSK1_domain1", "RSK1_domain2", "RSK1,RSK2_domain1", "RSK1,RSK2,RSK3_domain1", "RSK2_domain1", "RSK2_domain2", "RSK3_domain1", "RSKL1_domain1", "SGK3", "SLK", "SMG1", "SRC", "STLK5", "TAO1,TAOK3", "TAOK2", "TBK1", "TLK1", "TLK2", "ULK3", "VRK2", "WEE1", "Wnk1,Wnk2,Wnk3", "Wnk1,Wnk2,Wnk4", "WNK4", "ZC1/HGK", "ZC1/HGK,ZC2/TNIK,ZC3/MINK", "ZC2/TNIK", "ZC2/TNIK,ZC3/MINK" ], "_version_": 1815487279468118016 }, { "centerdatasetid": "http://lincs.hms.harvard.edu/db/datasets/20024/", "funding": "1U54HG006097-01", "projectname": "LINCS phase 1", "assayoverview": "The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tagged phage, a test compound, and an immobilized ligand that the compound competes with to displace the kinase. The amount of kinase bound to the immobilized ligand is determined using quantitative PCR of the DNA tag. Results for each kinase are reported as \"Percent of control\", where the control is DMSO and where a 100% result means no inhibition of kinase binding to the ligand in the presence of the compound, and where low percent results mean strong inhibition. The KINOMEscan data are presented graphically on TREEspot Kinase Dendrograms (http://www.kinomescan.com/Tools---Resources/Study-Reports---Data-Analysis). For this study, HMS LINCS investigators have graphed results for kinases classified as 35 \"percent of control\" (in the presence of the compound, the kinase is 35% as active for binding ligand in the presence of DMSO), 5 \"percent of control\" and 1 \"percent of control\". ", "centerurl": "http://lincs.hms.harvard.edu", "description": "For the panel of kinases, the percent of kinase bound by ligand is measured in the presence of PLX-4720 at 10 uM of concentration.", "principalinvestigator": "Nathanael Gray", "centerfullname": "HMS LINCS (Harvard Medical School)", "centername": "HMS_LINCS", "ldplink": "http://lincsportal.ccs.miami.edu/datasets/#/view/LDS-1010", "path": "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS", "protocol": "LDG-1009_Protocol.pdf", "datemodified": "2015-10-06", "centerletter": "H", "screeninglabinvestigator": "Qingsong Liu", "datasetname": "PLX-4720 KINOMEscan", "datasetid": "LDS-1010", "id": "7722", "datereleased": "2011-07-15", "assayname": [ "KINOMEscan kinase-small molecule binding assay" ], "assayformat": "Biochemical", "assaydesignmethod": [ "KINOMEscan" ], "physicaldetection": "Fluorescence intensity", "biologicalprocess": [ "Small molecule metabolic process" ], "technologies": "KINOMEscan", "biologicalbucket": "Binding", "endpointcategorization": "Protein binding profile", "endpoints": [ "percentControl" ], "levelspath": [ "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS" ], "datasetlevels": [ "LDS-1010" ], "latestversions": [ "1.1" ], "datalevels": [ "2" ], "size": [ "12968" ], "versions": [ "LDS-1010:1.0;1.1" ], "datasetgroup": "LDG-1009", "concentrations": [ "10 uM" ], "timepoints": [ "" ], "expentimentalcomments": [ "" ], "toollink": [ "http://amp.pharm.mssm.edu/Harmonizome/dataset/LINCS+KinomeScan+Kinase+Inhibitor+Targets", "http://life.ccs.miami.edu/life/search?load\u003dAssayTypeName\u0026search\u003dconcept%3A%26quot%3BKINOMEscan+assay%26quot%3B\u0026q\u003dconcept%3A%26quot%3BKINOMEscan+assay%26quot%3B" ], "tool": [ "Harmonizome", "Life" ], "statsfields": [ "protein", "smallmolecule" ], "counts": [ "protein:442", "smallmolecule:1" ], "statsvalues": [ "442", "1" ], "smlincsidentifier": [ "LSM-1049" ], "protein": [ "AAK1", "ABL1(E255K)-phosphorylated", "ABL1(F317I)-nonphosphorylated", "ABL1(F317I)-phosphorylated", "ABL1(F317L)-nonphosphorylated", "ABL1(F317L)-phosphorylated", "ABL1(H396P)-nonphosphorylated", "ABL1(H396P)-phosphorylated", "ABL1(M351T)-phosphorylated", "ABL1-nonphosphorylated", "ABL1-phosphorylated", "ABL1(Q252H)-nonphosphorylated", "ABL1(Q252H)-phosphorylated", "ABL1(T315I)-nonphosphorylated", "ABL1(T315I)-phosphorylated", "ABL1(Y253F)-phosphorylated", "ABL2", "ACVR1", "ACVR1B", "ACVR2A", "ACVR2B", "ACVRL1", "ADCK3", "ADCK4", "AKT1", "AKT2", "AKT3", "ALK", "AMPK-alpha1", "AMPK-alpha2", "ANKK1", "AURKA", "AURKB", "AURKC", "AXL", "BIKE", "BLK", "BMPR1A", "BMPR1B", "BMPR2", "BMX", "BRAF", "BRAF(V600E)", "BRSK1", "BRSK2", "BTK", "CAMK1", "CAMK1D", "CAMK1G", "CAMK2A", "CAMK2B", "CAMK2G", "CAMKK2", "CASK", "CDC2L1", "CDC2L2", "CDC2L5", "CDK11", "CDK14", "CDK15", "CDK16", "CDK2", "CDK3", "CDK4-cyclinD1", "CDK4-cyclinD3", "CDK5", "CDK7", "CDK8", "CDK9", "CDKL1", "CDKL2", "CDKL3", "CDKL5", "CHEK1", "CHK2", "CIT", "CLK1", "CLK2", "CLK3", "CLK4", "CSF1R", "CSK", "CSNK1A1", "CSNK1A1L", "CSNK1D", "CSNK1E", "CSNK1G3", "CSNK2A1", "CSNK2A2", "CTK", "DAPK1", "DAPK2", "DAPK3", "DCAMKL2", "DCAMKL3", "DCLK1", "DDR1", "DDR2", "DMPK", "DMPK2", "DRAK1", "DRAK2", "DYRK1A", "DYRK1B", "DYRK2", "EGFR", "EGFR(E746-A750del)", "EGFR(G719C)", "EGFR(G719S)", "EGFR(L747-E749del, A750P)", "EGFR(L747-S752del, P753S)", "EGFR(L747-T751del,Sins)", "EGFR(L858R)", "EGFR(L858R,T790M)", "EGFR(L861Q)", "EGFR(S752-I759del)", "EGFR(T790M)", "EIF2AK1", "EPHA1", "EPHA2", "EPHA3", "EPHA4", "EPHA5", "EPHA6", "EPHA7", "EPHA8", "EPHB1", "EPHB2", "EPHB3", "EPHB4", "EPHB6", "ERBB2", "ERBB3", "ERBB4", "ERK3", "ERK4", "ERK5", "ERK8", "ERN1", "FAK1", "FAK2", "FER", "FES", "FGFR1", "FGFR2", "FGFR3", "FGFR3(G697C)", "FGFR4", "FGR", "FLT3", "FLT3(D835H)", "FLT3(D835Y)", "FLT3(ITD)", "FLT3(K663Q)", "FLT3(N841I)", "FLT3(R834Q)", "FLT4", "FRK", "FYN", "GAK", "GCN2(Kin.Dom.2,S808G)", "GRK1", "GRK4", "GRK7", "GSK3A", "GSK3B", "HCK", "HIPK1", "HIPK2", "HIPK3", "HIPK4", "HUNK", "ICK", 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"IGF1R", "IKKA", "IKKB", "IKKE", "INSR", "INSRR", "IRAK1", "IRAK3", "IRAK4", "ITK", "JAK1(JH1domain-catalytic)", "JAK1(JH2domain-pseudokinase)", "JAK2(JH1domain-catalytic)", "JAK3(JH1domain-catalytic)", "JNK1", "JNK3", "KC1G1", "KC1G2", "KCC2D", "KCC4", "KGP1", "KGP2", "KIT", "KIT(A829P)", "KIT(D816H)", "KIT(D816V)", "KIT(L576P)", "KIT(V559D)", "KIT(V559D,T670I)", "KIT(V559D,V654A)", "KKCC1", "KPCD", "KPCD1", "KPCD2", "KPCD3", "KPCE", "KPCI", "KPCL", "KPCT", "LATS1", "LATS2", "LCK", "LIMK1", "LIMK2", "LKB1", "LOK", "LRRK2", "LRRK2(G2019S)", "LTK", "LYN", "M3K12", "M3K13", "M3K2", "M3K5", "M3K6", "M4K1", "M4K3", "MAK", "MAP3K1", "MAP3K15", "MAP3K3", "MAP3K4", "MAP4K2", "MAP4K4", "MAP4K5", "MAPKAPK2", "MAPKAPK5", "MARK1", "MARK2", "MARK3", "MARK4", "MAST1", "MELK", "MERTK", "MET", "MET(M1250T)", "MET(Y1235D)", "MINK", "MK01", "MK03", "MK09", "MK11", "MK12", "MK13", "MK14", "MKNK1", "MKNK2", "MLCK", "MLK1", "MLK2", "MLK3", "MLTK", "MP2K1", "MP2K2", "MP2K3", "MP2K4", "MP2K5", "MP2K6", "MP2K7", "MRCKA", "MRCKB", "MST1", "MST1R", "MST2", "MST3", "MST4", "MTOR", "MUSK", "MYLK", "MYLK2", "MYLK4", "MYO3A", "MYO3B", "NDR1", "NDR2", "NEK1", "NEK11", "NEK2", "NEK3", "NEK4", "NEK5", "NEK6", "NEK7", "NEK9", "NIM1", "NLK", "NUAK1", "OSR1", "PAK1", "PAK2", "PAK3", "PAK4", "PAK6", "PAK7", "PCTK2", "PCTK3", "PDPK1", "PFCDPK1(P.falciparum)", "PFPK5(P.falciparum)", "PGFRA", "PGFRB", "PHKG1", "PHKG2", "PI42C", "PIK3C2B", "PIK3C2G", "PIK3CA", "PIK3CA(C420R)", "PIK3CA(E542K)", "PIK3CA(E545A)", "PIK3CA(E545K)", "PIK3CA(H1047L)", "PIK3CA(H1047Y)", "PIK3CA(I800L)", "PIK3CA(M1043I)", "PIK3CA(Q546K)", "PIK3CB", "PIK3CD", "PIK3CG", "PIK4CB", "PIM1", "PIM2", "PIM3", "PIP5K1A", "PIP5K1C", "PIP5K2B", "PKAC-alpha", "PKAC-beta", "PKMYT1", "PKN1", "PKN2", "PKNB(M.tuberculosis)", "PLK1", "PLK2", "PLK3", "PLK4", "PRKR", "PRKX", "PRP4", "PTK6", "RAF1", "RET", "RET(M918T)", "RET(V804L)", "RET(V804M)", "RIOK1", "RIOK2", "RIOK3", "RIPK1", "RIPK2", "RIPK4", "RIPK5", "ROCK1", "ROCK2", "ROS1", "RPS6KA4(Kin.Dom.1-N-terminal)", "RPS6KA4(Kin.Dom.2-C-terminal)", "RPS6KA5(Kin.Dom.1-N-terminal)", "RPS6KA5(Kin.Dom.2-C-terminal)", "RSK1(Kin.Dom.1-N-terminal)", "RSK1(Kin.Dom.2-C-terminal)", "RSK2(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.2-C-terminal)", "RSK4(Kin.Dom.1-N-terminal)", "RSK4(Kin.Dom.2-C-terminal)", "S6K1", "SBK1", "SgK110", "SGK3", "SIK1", "SIK2", "SIK3", "SLK", "SNARK", "SNRK", "SRC", "SRMS", "SRPK1", "SRPK2", "SRPK3", "STK16", "STK33", "STK35", "STK36", "STK39", "SYK", "TAK1", "TAOK1", "TAOK2", "TAOK3", "TBK1", "TEC", "TESK1", "TGFBR1", "TGFBR2", "TIE1", "TIE2", "TLK1", "TLK2", "TNIK", "TNK1", "TNK2", "TNNI3K", "TRKA", "TRKB", "TRKC", "TRPM6", "TSSK1", "TTK", "TXK", "TYK2(JH1domain-catalytic)", "TYK2(JH2domain-pseudokinase)", "TYRO3", "ULK1", "ULK2", "ULK3", "VGFR1", "VGFR2", "VRK2", "WEE1", "WEE2", "YANK1", "YANK2", "YANK3", "YES", "YSK1", "YSK4", "ZAP70" ], "_version_": 1815487279614918656 }, { "centerdatasetid": "http://lincs.hms.harvard.edu/db/datasets/20034/", "funding": "1U54HG006097-01", "projectname": "LINCS phase 1", "assayoverview": "The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tagged phage, a test compound, and an immobilized ligand that the compound competes with to displace the kinase. The amount of kinase bound to the immobilized ligand is determined using quantitative PCR of the DNA tag. Results for each kinase are reported as \"Percent of control\", where the control is DMSO and where a 100% result means no inhibition of kinase binding to the ligand in the presence of the compound, and where low percent results mean strong inhibition. The KINOMEscan data are presented graphically on TREEspot Kinase Dendrograms (http://www.kinomescan.com/Tools---Resources/Study-Reports---Data-Analysis). For this study, HMS LINCS investigators have graphed results for kinases classified as 35 \"percent of control\" (in the presence of the compound, the kinase is 35% as active for binding ligand in the presence of DMSO), 5 \"percent of control\" and 1 \"percent of control\". ", "centerurl": "http://lincs.hms.harvard.edu", "description": "For the panel of kinases, the percent of kinase bound by ligand is measured in the presence of BMS345541 at 10 uM of concentration.", "principalinvestigator": "Nathanael Gray", "centerfullname": "HMS LINCS (Harvard Medical School)", "centername": "HMS_LINCS", "ldplink": "http://lincsportal.ccs.miami.edu/datasets/#/view/LDS-1020", "path": "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS", "protocol": "LDG-1019_Protocol.pdf", "datemodified": "2015-10-06", "centerletter": "H", "screeninglabinvestigator": "Qingsong Liu", "datasetname": "BMS345541 KINOMEscan", "datasetid": "LDS-1020", "id": "7732", "datereleased": "2011-07-15", "assayname": [ "KINOMEscan kinase-small molecule binding assay" ], "assayformat": "Biochemical", "assaydesignmethod": [ "KINOMEscan" ], "physicaldetection": "Fluorescence intensity", "biologicalprocess": [ "Small molecule metabolic process" ], "technologies": "KINOMEscan", "biologicalbucket": "Binding", "endpointcategorization": "Protein binding profile", "endpoints": [ "percentControl" ], "levelspath": [ "/projects/ccs/bd2klincs/LINCS_Data/HMS_LINCS" ], "datasetlevels": [ "LDS-1020" ], "latestversions": [ "1.1" ], "datalevels": [ "2" ], "size": [ "12751" ], "versions": [ "LDS-1020:1.0;1.1" ], "datasetgroup": "LDG-1019", "concentrations": [ "10 uM" ], "timepoints": [ "" ], "expentimentalcomments": [ "" ], "toollink": [ "http://amp.pharm.mssm.edu/Harmonizome/dataset/LINCS+KinomeScan+Kinase+Inhibitor+Targets", "http://life.ccs.miami.edu/life/search?load\u003dAssayTypeName\u0026search\u003dconcept%3A%26quot%3BKINOMEscan+assay%26quot%3B\u0026q\u003dconcept%3A%26quot%3BKINOMEscan+assay%26quot%3B" ], "tool": [ "Harmonizome", "Life" ], "statsfields": [ "protein", "smallmolecule" ], "counts": [ "protein:442", "smallmolecule:1" ], "statsvalues": [ "442", "1" ], "smlincsidentifier": [ "LSM-1028" ], "protein": [ "AAK1", "ABL1(E255K)-phosphorylated", "ABL1(F317I)-nonphosphorylated", "ABL1(F317I)-phosphorylated", "ABL1(F317L)-nonphosphorylated", "ABL1(F317L)-phosphorylated", "ABL1(H396P)-nonphosphorylated", "ABL1(H396P)-phosphorylated", "ABL1(M351T)-phosphorylated", "ABL1-nonphosphorylated", "ABL1-phosphorylated", "ABL1(Q252H)-nonphosphorylated", "ABL1(Q252H)-phosphorylated", "ABL1(T315I)-nonphosphorylated", "ABL1(T315I)-phosphorylated", "ABL1(Y253F)-phosphorylated", "ABL2", "ACVR1", "ACVR1B", "ACVR2A", "ACVR2B", "ACVRL1", "ADCK3", "ADCK4", "AKT1", "AKT2", "AKT3", "ALK", "AMPK-alpha1", "AMPK-alpha2", "ANKK1", "AURKA", "AURKB", "AURKC", "AXL", "BIKE", "BLK", "BMPR1A", "BMPR1B", "BMPR2", "BMX", "BRAF", "BRAF(V600E)", "BRSK1", "BRSK2", "BTK", "CAMK1", "CAMK1D", "CAMK1G", "CAMK2A", "CAMK2B", "CAMK2G", "CAMKK2", "CASK", "CDC2L1", "CDC2L2", "CDC2L5", "CDK11", "CDK14", "CDK15", "CDK16", "CDK2", "CDK3", "CDK4-cyclinD1", "CDK4-cyclinD3", "CDK5", "CDK7", "CDK8", "CDK9", "CDKL1", "CDKL2", "CDKL3", "CDKL5", "CHEK1", "CHK2", "CIT", "CLK1", "CLK2", "CLK3", "CLK4", "CSF1R", "CSK", "CSNK1A1", "CSNK1A1L", "CSNK1D", "CSNK1E", "CSNK1G3", "CSNK2A1", "CSNK2A2", "CTK", "DAPK1", "DAPK2", "DAPK3", "DCAMKL2", "DCAMKL3", "DCLK1", "DDR1", "DDR2", "DMPK", "DMPK2", "DRAK1", "DRAK2", "DYRK1A", "DYRK1B", "DYRK2", "EGFR", "EGFR(E746-A750del)", "EGFR(G719C)", "EGFR(G719S)", "EGFR(L747-E749del, A750P)", "EGFR(L747-S752del, P753S)", "EGFR(L747-T751del,Sins)", "EGFR(L858R)", "EGFR(L858R,T790M)", "EGFR(L861Q)", "EGFR(S752-I759del)", "EGFR(T790M)", "EIF2AK1", "EPHA1", "EPHA2", "EPHA3", "EPHA4", "EPHA5", "EPHA6", "EPHA7", "EPHA8", "EPHB1", "EPHB2", "EPHB3", "EPHB4", "EPHB6", "ERBB2", "ERBB3", "ERBB4", "ERK3", "ERK4", "ERK5", "ERK8", "ERN1", "FAK1", "FAK2", "FER", "FES", "FGFR1", "FGFR2", "FGFR3", "FGFR3(G697C)", "FGFR4", "FGR", "FLT3", "FLT3(D835H)", "FLT3(D835Y)", "FLT3(ITD)", "FLT3(K663Q)", "FLT3(N841I)", "FLT3(R834Q)", "FLT4", "FRK", "FYN", "GAK", "GCN2(Kin.Dom.2,S808G)", "GRK1", "GRK4", "GRK7", "GSK3A", "GSK3B", "HCK", "HIPK1", "HIPK2", "HIPK3", "HIPK4", "HUNK", "ICK", "IGF1R", "IKKA", "IKKB", "IKKE", "INSR", "INSRR", "IRAK1", "IRAK3", "IRAK4", "ITK", "JAK1(JH1domain-catalytic)", "JAK1(JH2domain-pseudokinase)", "JAK2(JH1domain-catalytic)", "JAK3(JH1domain-catalytic)", "JNK1", "JNK3", "KC1G1", "KC1G2", "KCC2D", "KCC4", "KGP1", "KGP2", "KIT", "KIT(A829P)", "KIT(D816H)", "KIT(D816V)", "KIT(L576P)", "KIT(V559D)", "KIT(V559D,T670I)", "KIT(V559D,V654A)", "KKCC1", "KPCD", "KPCD1", "KPCD2", "KPCD3", "KPCE", "KPCI", "KPCL", "KPCT", "LATS1", "LATS2", "LCK", "LIMK1", "LIMK2", "LKB1", "LOK", "LRRK2", "LRRK2(G2019S)", "LTK", "LYN", "M3K12", "M3K13", "M3K2", "M3K5", "M3K6", "M4K1", "M4K3", "MAK", "MAP3K1", "MAP3K15", "MAP3K3", "MAP3K4", "MAP4K2", "MAP4K4", "MAP4K5", "MAPKAPK2", "MAPKAPK5", "MARK1", "MARK2", "MARK3", "MARK4", "MAST1", "MELK", "MERTK", "MET", "MET(M1250T)", "MET(Y1235D)", "MINK", "MK01", "MK03", "MK09", "MK11", "MK12", "MK13", "MK14", "MKNK1", "MKNK2", "MLCK", "MLK1", "MLK2", "MLK3", "MLTK", "MP2K1", "MP2K2", "MP2K3", "MP2K4", "MP2K5", "MP2K6", "MP2K7", "MRCKA", "MRCKB", "MST1", "MST1R", "MST2", "MST3", "MST4", "MTOR", "MUSK", "MYLK", "MYLK2", "MYLK4", "MYO3A", "MYO3B", "NDR1", "NDR2", "NEK1", "NEK11", "NEK2", "NEK3", "NEK4", "NEK5", "NEK6", "NEK7", "NEK9", "NIM1", "NLK", "NUAK1", "OSR1", "PAK1", "PAK2", "PAK3", "PAK4", "PAK6", "PAK7", "PCTK2", "PCTK3", "PDPK1", "PFCDPK1(P.falciparum)", "PFPK5(P.falciparum)", "PGFRA", "PGFRB", "PHKG1", "PHKG2", "PI42C", "PIK3C2B", "PIK3C2G", "PIK3CA", "PIK3CA(C420R)", "PIK3CA(E542K)", "PIK3CA(E545A)", "PIK3CA(E545K)", "PIK3CA(H1047L)", "PIK3CA(H1047Y)", "PIK3CA(I800L)", "PIK3CA(M1043I)", "PIK3CA(Q546K)", "PIK3CB", "PIK3CD", "PIK3CG", "PIK4CB", "PIM1", "PIM2", "PIM3", "PIP5K1A", "PIP5K1C", "PIP5K2B", "PKAC-alpha", "PKAC-beta", "PKMYT1", "PKN1", "PKN2", "PKNB(M.tuberculosis)", "PLK1", "PLK2", "PLK3", "PLK4", "PRKR", "PRKX", "PRP4", "PTK6", "RAF1", "RET", "RET(M918T)", "RET(V804L)", "RET(V804M)", "RIOK1", "RIOK2", "RIOK3", "RIPK1", "RIPK2", "RIPK4", "RIPK5", "ROCK1", "ROCK2", "ROS1", "RPS6KA4(Kin.Dom.1-N-terminal)", "RPS6KA4(Kin.Dom.2-C-terminal)", "RPS6KA5(Kin.Dom.1-N-terminal)", "RPS6KA5(Kin.Dom.2-C-terminal)", "RSK1(Kin.Dom.1-N-terminal)", "RSK1(Kin.Dom.2-C-terminal)", "RSK2(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.1-N-terminal)", "RSK3(Kin.Dom.2-C-terminal)", "RSK4(Kin.Dom.1-N-terminal)", "RSK4(Kin.Dom.2-C-terminal)", "S6K1", "SBK1", "SgK110", "SGK3", "SIK1", "SIK2", "SIK3", "SLK", "SNARK", "SNRK", "SRC", "SRMS", "SRPK1", "SRPK2", "SRPK3", "STK16", "STK33", "STK35", "STK36", "STK39", "SYK", "TAK1", "TAOK1", "TAOK2", "TAOK3", "TBK1", "TEC", "TESK1", "TGFBR1", "TGFBR2", "TIE1", "TIE2", "TLK1", "TLK2", "TNIK", "TNK1", "TNK2", "TNNI3K", "TRKA", "TRKB", "TRKC", "TRPM6", "TSSK1", "TTK", "TXK", "TYK2(JH1domain-catalytic)", "TYK2(JH2domain-pseudokinase)", "TYRO3", "ULK1", "ULK2", "ULK3", "VGFR1", "VGFR2", "VRK2", "WEE1", "WEE2", "YANK1", "YANK2", "YANK3", "YES", "YSK1", "YSK4", "ZAP70" ], "_version_": 1815487279667347456 } ]}}